Ausgewählte Publikationen

Wissenschaftliche Aktivität ist der Schlüssel zu Innovation und Fortschritt. Wir beschäftigen uns nicht nur klinisch sondern auch wissenschaftlich mit entscheidenden Fragestellungen rund um das Pankreaskarzinom. Auf diesen Seiten finden Sie eine Auswahl von entscheidenden Artikeln, die das Zentrum in den letzten Jahren veröffentlicht hat.

Publikationen aus dem Jahr 2012

 
 
01. Sep. 2012

Randomized controlled single-center trial comparing pancreatogastrostomy versus pancreaticojejunostomy after partial pancreatoduodenectomy

BACKGROUND: The aim of this single-center randomized trial was to compare the perioperative outcome of pancreatoduodenectomy with pancreatogastrostomy (PG) vs pancreaticojejunostomy (PJ). 

METHODS: Randomization was done intraoperatively. PG was performed via anterior and posterior gastrotomy with pursestring and inverting seromuscular suture;control intervention was PJ with duct-mucosa anastomosis. The primary endpoint was postoperative pancreatic fistula (POPF).

CONCLUSIONS: Our randomized controlled trial shows no difference between PG and PJ as reconstruction techniques after partial pancreatoduodenectomy. POPF rate,DGE, and bleeding were not statistically different. Operation time was significantly shorter in the PG group.

01. Sep. 2012

Short- and long-term results of duodenum preservation versus resection for the management of chronic pancreatitis: a prospective, randomized study

BACKGROUND: Individualization of operations for chronic pancreatitis (CP) offers tailored operative approaches for the management of complications of CP. For the management of the inflammatory head mass and its complications, duodenum-preserving procedures (Frey and Beger operations) compete in efficacy and quality of life with pancreatoduodenectomy procedures (PPPD and Whipple operations). Our aim was to compare the short- and long-term results of duodenum-preserving and duodenum-resecting techniques in a prospective, randomized trial.

CONCLUSION: Both types of pancreatic head resections are equally effective in pain relief and eventual quality of life after long-term follow-up (>5 years)without differences in endocrine or exocrine function.

01. Jul. 2012

The pathobiological impact of cigarette smoke on pancreatic cancer development (review)

Despite extensive efforts, pancreatic cancer remains incurable. Most risk factors, such as genetic disposition, metabolic diseases or chronic pancreatitis cannot be influenced. By contrast, cigarette smoking, an important risk factor for pancreatic cancer, can be controlled. Despite the epidemiological evidence of the detrimental effects of cigarette smoking with regard to pancreatic cancer development and its unique property of being influenceable, our understanding of cigarette smoke-induced pancreatic carcinogenesis is limited. Current data on cigarette smoke-induced pancreatic carcinogenesis indicate multifactorial events that are triggered by nicotine, which is the major pharmacologically active constituent of tobacco smoke.

In addition to nicotine, a vast number of carcinogens have the potential to reach the pancreatic gland, where they are metabolized, in some instances to even more toxic compounds. These metabolic events are not restricted to pancreatic ductal cells. Several studies show that acinar cells are also greatly affected. Furthermore, pancreatic cancer progenitor cells do not only derive from the ductal epithelial lineage, but also from acinar cells. This sheds new light on cigarette smoke-induced acinar cell damage. On this background, our objective is to outline a multifactorial model of tobacco smoke-induced pancreatic carcinogenesis. 

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